compound 16 Search Results


crm  (LGC Standards)
94
LGC Standards crm
Crm, supplied by LGC Standards, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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materials 2 cl trityl chloride resin  (Chem Impex International)
95
Chem Impex International materials 2 cl trityl chloride resin
Materials 2 Cl Trityl Chloride Resin, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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materials 2 cl trityl chloride resin - by Bioz Stars, 2026-08
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compound 1  (Chem Impex International)
95
Chem Impex International compound 1
Compound 1, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound 1 - by Bioz Stars, 2026-08
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compound  (Chem Impex International)
95
Chem Impex International compound
Compound, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+16/pm27294199__id6b00007_si_001-79-0-4?v=Chem+Impex+International
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compound - by Bioz Stars, 2026-08
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17α estradiol  (LGC Standards)
91
LGC Standards 17α estradiol
17α Estradiol, supplied by LGC Standards, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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commercial compound library  (BioFocus DPI)
90
BioFocus DPI commercial compound library
Commercial Compound Library, supplied by BioFocus DPI, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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commercial compound library - by Bioz Stars, 2026-08
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chemical compounds dpp-1, 3, 5, 7, 10, 12, 14, 15, 16, 27, 28, 19, and 20  (MolPort Inc)
90
MolPort Inc chemical compounds dpp-1, 3, 5, 7, 10, 12, 14, 15, 16, 27, 28, 19, and 20
Chemical Compounds Dpp 1, 3, 5, 7, 10, 12, 14, 15, 16, 27, 28, 19, And 20, supplied by MolPort Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
chemical compounds dpp-1, 3, 5, 7, 10, 12, 14, 15, 16, 27, 28, 19, and 20 - by Bioz Stars, 2026-08
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crm pah 16 compounds mix 500 ug/ml  (Reagecon)
90
Reagecon crm pah 16 compounds mix 500 ug/ml
Crm Pah 16 Compounds Mix 500 Ug/Ml, supplied by Reagecon, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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us-epa 16 pah cocktail  (Cambridge Isotope Laboratories)
90
Cambridge Isotope Laboratories us-epa 16 pah cocktail
Us Epa 16 Pah Cocktail, supplied by Cambridge Isotope Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound 16 (pfi-3) profiled in biomap  (DiscoverX corporation)
90
DiscoverX corporation compound 16 (pfi-3) profiled in biomap
DSF thermal shift (°C stabilization, 10 μM compound) SAR for <t> Family VIII bromodomains. </t> Values are derived from at least three determinations with standard deviations quoted.
Compound 16 (Pfi 3) Profiled In Biomap, supplied by DiscoverX corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+16/pmc05034155-134-12-23?v=DiscoverX+corporation
Average 90 stars, based on 1 article reviews
compound 16 (pfi-3) profiled in biomap - by Bioz Stars, 2026-08
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compounds 1-3, 12-14, 16 and 19-20  (FUJIFILM)
90
FUJIFILM compounds 1-3, 12-14, 16 and 19-20
DSF thermal shift (°C stabilization, 10 μM compound) SAR for <t> Family VIII bromodomains. </t> Values are derived from at least three determinations with standard deviations quoted.
Compounds 1 3, 12 14, 16 And 19 20, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
compounds 1-3, 12-14, 16 and 19-20 - by Bioz Stars, 2026-08
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compound 16  (MultiTarget Pharmaceuticals)
90
MultiTarget Pharmaceuticals compound 16
DSF thermal shift (°C stabilization, 10 μM compound) SAR for <t> Family VIII bromodomains. </t> Values are derived from at least three determinations with standard deviations quoted.
Compound 16, supplied by MultiTarget Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+16/pmc06071942-297-2-11?v=MultiTarget+Pharmaceuticals
Average 90 stars, based on 1 article reviews
compound 16 - by Bioz Stars, 2026-08
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Image Search Results


DSF thermal shift (°C stabilization, 10 μM compound) SAR for Family VIII bromodomains. Values are derived from at least three determinations with standard deviations quoted.

Journal: Journal of medicinal chemistry

Article Title: Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit

doi: 10.1021/acs.jmedchem.6b00012

Figure Lengend Snippet: DSF thermal shift (°C stabilization, 10 μM compound) SAR for Family VIII bromodomains. Values are derived from at least three determinations with standard deviations quoted.

Article Snippet: With nothing known about potential phenotypes derived from small molecule binding to Family VIII bromodomains, compound 16 (PFI-3) was profiled in BioMAP by DiscoveRx.

Techniques: Derivative Assay

Compound 17 is a potent pan-inhibitor of SMARCA2/SMARCA4 and PB1 families. (A) Chemical structure of inhibitor 17. (B) Isothermal titration data of the interaction of compound 17. Top panel shows the raw binding exotherms for each SMARCA2 injection into the cell containing the inhibitor solution. Bottom panel displays normalized binding enthalpies and the corresponding non-linear least squares fits (Insert) for the two families SMARCA2/SMARCA4 and PB1 bromodomains. (C) 2Fo-Fc electron density map contoured at 1.5 σ around the inhibitor at 1.7 Å resolution. (D) Complex of SMARCA2 with compound 17. The hydroxyphenyl propenone core scaffold adopts the same conformation of previous crystallized analogues in the acetyl-lysine binding site. The cyclopropanamine group is pointing towards the ZA-loop stabilized by hydrophobic interactions with the lipophilic side chains of L1418, P1413 and E1417. (E) Surface representation of the SMARCA2 acetyl-lysine binding site in complex with compound 17.

Journal: Journal of medicinal chemistry

Article Title: Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit

doi: 10.1021/acs.jmedchem.6b00012

Figure Lengend Snippet: Compound 17 is a potent pan-inhibitor of SMARCA2/SMARCA4 and PB1 families. (A) Chemical structure of inhibitor 17. (B) Isothermal titration data of the interaction of compound 17. Top panel shows the raw binding exotherms for each SMARCA2 injection into the cell containing the inhibitor solution. Bottom panel displays normalized binding enthalpies and the corresponding non-linear least squares fits (Insert) for the two families SMARCA2/SMARCA4 and PB1 bromodomains. (C) 2Fo-Fc electron density map contoured at 1.5 σ around the inhibitor at 1.7 Å resolution. (D) Complex of SMARCA2 with compound 17. The hydroxyphenyl propenone core scaffold adopts the same conformation of previous crystallized analogues in the acetyl-lysine binding site. The cyclopropanamine group is pointing towards the ZA-loop stabilized by hydrophobic interactions with the lipophilic side chains of L1418, P1413 and E1417. (E) Surface representation of the SMARCA2 acetyl-lysine binding site in complex with compound 17.

Article Snippet: With nothing known about potential phenotypes derived from small molecule binding to Family VIII bromodomains, compound 16 (PFI-3) was profiled in BioMAP by DiscoveRx.

Techniques: Titration, Binding Assay, Injection, Analogues